CASC3 also appears to be very strongly downregulated by TUBB4B, MRPS25 a mitochondrial ribosomal subunit involved in mitochondrial translation and organelle maintenance and biosynthesis, and FARSB, a Phenylalanyl-TRNA Synthetase Beta Subunit involved in tRNA aminoacylation and has been found to be associated with muscular dystrophy. The gene discussed is FARSB; the disease is muscular dystrophy.