CDK1 and neoplasm: Most of these hub genes including CDK1 [32], CENPF [33], CCNB2 [34], MELK [35], CENPE [36], KIF20A [37], KIF4A [38], PBK [39], and DLGAP5 [40] have been proven to be responsible for the cell cycle-associated proliferation and differentiation of tumor.