The majority of RCTs designed to investigate the effect of prenatal ω-3 LCPUFA supplementation on childhood allergy have been driven by the plausible hypothesis that diets high in ω-3 LCPUFAs may modulate the development of immunoglobulin E (IgE) associated allergic disease [14–18, 23]. The gene discussed is IGHE; the disease is allergic disease.