It is well known that adipose tissue is implicated in the secretion of several hormones such as adiponectin, resistin, leptin, visfatin, and apelin called adipokines “adipose tissue-derived hormones.” There is evidence that the increased production of adipokines might have a strong link to insulin resistance, metabolic syndrome, and obesity [1]. Here, APLN is linked to obesity due to melanocortin 4 receptor deficiency.