CDKL5 and Anxiety: Cdkl5 +/+, Cdkl5 +/−, and Cdkl5 −/− spent a comparable time at the border [F(2, 54) = 1.135, p = 0.3289], near the walls [F(2, 54) = 0.6457, p = 0.5285], and in the center [F(2, 54) = 0.4563, p = 0.6361] (Figure 3(f)), suggesting that the increased locomotor activity is not due to increased anxiety.