CXCL8 and chronic obstructive pulmonary disease: Furthermore, monocytes from COPD patients (37 patients, 24 males, FEV1% 47) show increased chemotactic response toward growth-related oncogene (GRO) alpha/CXCL1 and neutrophil-activating peptide (NAP)-2/CXCL7, but not toward IL-8, when compared with controls (44).