In addition to these two, COPD lung tissue is found to release more RANTES/CCL5, suggesting a role for CCL5-CCR3 signaling in the recruitment of pulmonary CD8+ T cells in COPD patients (15 patients, mean age 64.6 years, 4 males, FEV1% 64) (73). This evidence concerns the gene CCL5 and chronic obstructive pulmonary disease.