In contrast, Sapey et al. (24) found that neutrophils from COPD patients (20 patients, mean age 60 years, 11 males, FEV1% 44) show higher migratory speed of movement in any direction but lower migratory accuracy toward inflammation, which is correlated to systemic neutrophil elastase (NE) activity. This evidence concerns the gene ELANE and chronic obstructive pulmonary disease.