TLR7 and Psoriasiform dermatitis: To clarify the kinetics for the expression of IL-22BP during the skin inflammation, we accessed the expression level of the Il22ra2 transcript in the skin and skin-draining PLNs in psoriasiform dermatitis induced by topical application of imiquimod (IMQ), known as a synthetic Toll-like receptor 7 (TLR7) ligand on the ear skin (29, 30).