CD274 and cutaneous melanoma: Consistent with our cell surface expression data, the expression of HLA-DRA, NGFR, and PD-L2 transcripts was significantly lower in the 80 uveal compared to the 472 cutaneous melanoma samples from the TCGA dataset; CD274 (PD-L1) transcript expression was also different between the TCGA uveal and cutaneous datasets, whereas HLA-A transcript expression was indistinguishable between the TCGA uveal and cutaneous tumor groups (Figure 2B).