Metastatic UVM respond poorly to immune checkpoint inhibition (28, 29), and although there appears to be no difference in the level of infiltrating CD8+ T cells between uveal and cutaneous melanoma (30), our data suggest that UVM may have diminished capacity to respond to IFNγ, with lower expression of targets including PD-L1 (31), PD-L2, HLA-DR, and NGFR (this study). The gene discussed is CD8A; the disease is cutaneous melanoma.