In contrast to secretion of IFN-γ by splenocytes, PBMCs, pancreas and adipose tissues, in which an upregulation of cytokine secretion could be seen in mice on HFCD, NK cells treated with IL-2 (Figure 1D; Tables S1, S3, S4 and S5 in Supplementary Material) or with IL-2 + LPS (Figure 1E) from KC mice fed with HFCD had the least secretion of IFN-γ, followed by KC mice fed with CD (Figures 1D,E; Table S5 in Supplementary Material). Here, IFNG is linked to keratoconus.