CXCL8 and cancer: Owing to its potent pro-inflammatory properties, CXCL8 expression in normal tissues is low or undetectable (81), while an increased expression of CXCL8 was detected in several human solid tumors such as melanoma (88), squamous cell carcinoma (89), cervical (90), ovarian (91), non-small cell lung (92), colon (93), and gastric (94) cancers.