AKT1 and cancer: The Ras/MAPK/ERK and PI3K/AKT signaling pathways play crucial roles in multiple cancer cells and are highly related to tumor development (Sebolt-Leopold and Herrera, 2004; Vitucci et al., 2013; Tsai et al., 2015; Xiang et al., 2017; De Araújo et al., 2018).