As a secreted lipid binding protein that binds to Wnt proteins and inhibits Wnt signaling pathway, Wnt inhibitory factor-1 (WIF-1) is identified as a direct and functional target of miR-181a in colorectal cancer, and an ectopic expression of miR-181a promotes tumor growth and liver metastasis (Ji et al., 2014). Here, WIF1 is linked to colorectal cancer.