Ji et al. (2011) reported that several putative β-catenin/TCF4 binding sites are identified in the promoter region of the miRNA-181a-2 and miRNA-181b-2 transcripts, and four members in miRNA-181 family are positively associated with β-catenin expression in HCC. This is in line with the previous report which demonstrates that miR-183/96/182 cluster is activated by Wnt/β-catenin/TCF3 signaling in HCC and promotes cell migration and invasion (Leung et al., 2015). This evidence concerns the gene TCF4 and hepatocellular carcinoma.