MYC and hepatocellular carcinoma: For instant, Wu et al. demonstrated that a regulatory feedback loop exists between miR-17-5p and c-Myc, in which miR-17-5p could inhibit metastasis and invasion of HCC cells by suppressing c-Myc, and miR-17-5p, in turn, is induced by activated c-Myc as a transcription factor, although detailed mechanism is still needed to be elucidated (Liu et al., 2016).