LRRK2 has been proposed to function in a wide variety of cellular processes, including vesicle trafficking and endocytosis, autophagy, regulation of the retromer complex as well as mitochondrial function and, in turn, dysregulation of these processes is reported for diverse PD-associated LRRK2 mutations (Wallings et al., 2015). The gene discussed is LRRK2; the disease is Parkinson disease.