Anti-HEV IgM was not detected in any donor (Fig. 3b, upper panel), but positivity for anti-HEV IgM and anti-HEV IgG was observed at the time of the first sample collection and persisted for 224 days after the onset of symptoms in most HE patients (Fig. 3b, lower panel). Here, CD40LG is linked to hereditary elliptocytosis.