Recently it has been proposed that DIZE activates ACE2, likely resulting in increased angiotensin-(1-7) (Ang-(1-7)) generation from angiotensin II (Ang II)7, which produces beneficial effects in a number of animal models including experimental pulmonary hypertension, myocardial infarction, and kidney disease5,8–11. The gene discussed is AGT; the disease is pulmonary hypertension.