IHC analysis confirmed the reduced levels of Ki67, Gli1, and VEGFR2 in FOXC1-silenced xenograft tumors (Fig. 6e), whereas FOXC1 overexpression upregulated these proliferative and metastatic markers compared with the xenograft tumors from empty vector control tumor group (Fig. 6f). This evidence concerns the gene MKI67 and neoplasm.