We assessed the effects of hypoxia on the expression of the pro-invasive and -metastatic invadopodial protein CSRP2 in four breast cancer cell lines, including luminal/epithelial-like MCF-7 and T47D (ER+, PR+), and mesenchymal-like MDA-MB-231 and Hs578T (ER−, PR−, HER2−, claudin-low). Here, CSRP2 is linked to breast cancer.