WFS1 and Glucose intolerance: Before liraglutide treatment, Wfs1 KO animals showed glucose intolerance (Fig. 2b) (F(1,12) = 28.28, p < 0.001 (genotype); F(1,12) = 63.67, p < 0.001 (treatment); F(1,12) = 26.16, p < 0.001 (genotype × treatment)); however, after 8-day repeated treatment with 0.4 mg1kg−1day−1 liraglutide, the difference between the genotypes disappeared (Fig. 2a); area-under-curve analysis confirmed this finding (Fig. 2b) (p > 0.05).