COL1A1 and Hepatic fibrosis: Since the transcription of key gene collagen type I α1 chain (COL1A1) for liver fibrosis could be activated by TGFβ1 through TGFβ/Smad pathway [7], a high-throughput drug screening cell model based on COL1A1 promotor was established earlier in our group, in which the activity of COL1A1 promotor and luciferase reporter gene could be elevated by TGFβ1, and inhibited by candidate agents [8].