FMO5 and chronic kidney disease: This characteristic of IS as a ROS-inducer has been shown in different cell types with adverse consequences, such as not only impair renal cells functions, but also aggravate the progression of CKD [18,19,32], and also has harmful effects on endothelial cells, since the ROS production induced by IS was observed the increase of the NADPH oxidase activity with decreased glutathione levels [24].