If all of these regulatory mechanisms fail, hyperactivation of TLR2 can cause autoimmune inflammatory diseases such as atopic dermatitis, acne vulgaris, ischemia, and rheumatoid arthritis (RA) [11,12]; thus, TLR2 inhibitors are essential for the control or treatment of these disorders [4,13]. The gene discussed is TLR2; the disease is rheumatoid arthritis.