INS and Sepsis: The PPAR‐γ agonist thiazolidinedione (TZD) was shown to improve peripheral insulin sensitivity and clearance of TGs in type 2 diabetes (Mayerson et al, 2002), while ameliorating murine polymicrobial sepsis by reducing the pro‐inflammatory signal transducer and activator of transcription‐1 (STAT‐1) signaling pathway (Ferreira et al, 2014).