Furthermore, the genotypes frequencies at rs2273773 in SIRT1 had no significant difference between the COPD patients and controls, which is not in line with the previous observation reported by Kalemci et al. [34] that there is a significant difference between TT, TC, and CC genotypes of rs2273773 in the same different group in Muğla province. Here, SIRT1 is linked to chronic obstructive pulmonary disease.