The increased synthesis of IL-1β [16], IL-6 and IL-8 can induce the expression of other proinflammatory genes including COX-2 (ciclo-oxigenase-2) and CCL20 by the adjacent fibroblasts and attract, among other inflammatory cells, tumor-associated macrophages (TAM) and Th17 cells (Fig. 1) [5]. This evidence concerns the gene IL1B and neoplasm.