Both ligands induced a downregulation of NKG2D expression [94, 98] and this is suggested to be an immune evasion mechanism performed by hrHPV to lead to cancer development [120], since the engagement of NKG2D and MICA/MICB plays an important role in cervical and other cancer immune surveillance [95, 98, 117, 118, 121]. Here, MICB is linked to cancer.