Moreover, the patients with cervical cancer or with high-grade lesions have shown a reduced expression of NKG2D, NKp30 and NKp46 [94, 95], the same receptors which were found with increased levels after the administration of the quadrivalent [101] and bivalent (NKG2D) [102] vaccines and supported host immune response. The gene discussed is KLRK1; the disease is cervical cancer.