Our results showed that the relative mRNA levels of CTSG (DM patients 11.09 ± 3.02, PM patients 25.36 ± 8.16), NE (DM patients 5.80 ± 1.54, PM patients 2.50 ± 0.69), and PR3 (DM patients 12.64 ± 2.74, PM patients 9.21 ± 2.54) were significantly upregulated in DM/PM patients compared to those of normal controls (CTSG 1.29 ± 0.32, NE 0.44 ± 0.09, PR3 0.71 ± 0.16) (Fig. 1a–c). This evidence concerns the gene CTSG and dermatomyositis.