GJA1 and Cerebral ischemia: However, Cx43 might be harmful during ischemia-reperfusion according to most reports [22], and some studies are not supportive of our previous results, which may relate to the use of different in vivo and in vitro models, different mechanisms during different stages of cerebral ischemia and reperfusion, and the expression of other proteins associated with the formation of gap junctions, such as Cx30 [23–25].