CCL2 and early-onset autosomal dominant Alzheimer disease: Elevated MCP-1 levels have been observed in brains which undergo various pathogenesis processes, such as multiple sclerosis [14, 15], stroke [16, 17], and Alzheimer’s disease patients [18, 19], and it is believed that the upregulation of MCP-1 is involved in the progression of these diseases [15, 16, 19].