ABCC6 gene is affected in the classic form of PXE and so, in the same way as there is an overlap in clinical phenotypes, there is a genotypic overlap between GACI and PXE: some patients with GACI harbor mutations in ABCC6, and some patients with clinical manifestations consistent with PXE have mutations in ENPP1 [2]. Here, ENPP1 is linked to pseudoxanthoma elasticum (inherited or acquired).