It was demonstrated that the level of HERV expression in the PBMC compartment is modulated in solid organ cancers, autoimmune diseases, infectious diseases, as well as immunocompromised states, e.g. HML-2 in prostate cancer [37], HERV-W/MSRV in multiple sclerosis [38], HERV-W in EBV-infected multiple sclerosis patients [39], and HML-2 in HIV infected patients [40]. Here, CLEC10A is linked to multiple sclerosis.