Conversely, although spread on various chromosomes, a bundle of 8 HERV/MaLR elements contributed to both the LXR/RXR activation pathway activated under ET condition and the NF-κB signalling pathway activated during inflammation, via PTGS2 and FLT1 genes (see Additional file 9: Figure S7e). Here, NFKB1 is linked to essential thrombocythemia.