Our data showed that MASTL depletion preferentially induced cancer cell death in breast cancer cells with high MASTL expression, whereas MASTL depletion did not affect the viability of normal cell lines with almost non-existent expression of MASTL (Fig. 4), which implied that breast cancer cells with high MASTL expression may be reliant on MASTL overexpression for survival and proliferation. This evidence concerns the gene MASTL and breast carcinoma.