Most of the reported CNVs span genes involved in cell adhesion (N = 14): CDH13, CTNNA3, DIAPH3, CDH9, CDH6, KIF26B, CDH4, CNTNAP2, SGCZ, HIPK3, CSTF3 and CNTN6. Hence we support Lesca G et al in suggesting that, these genes might explain the role of autoimmunity in the pathogenesis of ESESS/CSWSS/epilepsy-aphasia spectrum [12]. This evidence concerns the gene CDH4 and Autoimmunity.