TCF4 and colorectal cancer: However, as dysregulation of the Wnt signaling pathway plays an important role in the development of colorectal cancer the shift from wild type TCF4, that can function as a transcriptional activator, to the dominant negative VTI1A-TCF4 in mutated colonic cells will most likely have an effect on colon homeostasis and may perhaps contribute to the development of colorectal cancer.