However, as dysregulation of the Wnt signaling pathway plays an important role in the development of colorectal cancer the shift from wild type TCF4, that can function as a transcriptional activator, to the dominant negative VTI1A-TCF4 in mutated colonic cells will most likely have an effect on colon homeostasis and may perhaps contribute to the development of colorectal cancer. Here, VTI1A is linked to colorectal cancer.