Furthermore, LysM Cre mice were used to demonstrate that microglial progranulin deficiency increases plaque deposition and impairs phagocytosis in AD [74] and that targeted expression of MECP2 in myeloid cells, driven by LysM Cre promoter in an Mecp2-null background attenuated pathology in a mouse model of Rett syndrome [46]. Here, GRN is linked to Alzheimer disease.