However, different carcinomas with the same histological subtype may have distinct prognoses associated with a variable growth potential, degree of cancer extension beyond the capsule, and patterns of specific protein expression, such as Ki-67, epidermoid growth factor receptor (EGFR), HER2, c-kit, and vascular endothelial growth factor (VEGF) [1, 6]. The gene discussed is ERBB2; the disease is cancer.