RAG1 and cervical carcinoma: We had previously shown, using both the TC-1 tumor model injected into C57Black/6 immunocompetent mice [25], or cervical cancer derived cell lines, SiHa, HeLa and C33A injected into Nude or RAG1-/- immunodeficient mice [38], that HPV associated tumors induced proliferation of myeloid cells in the bone marrow and spleen, which had tolerogenic activity, suppressing T cells [29].