Moreover, the function of Tregs has been shown impaired in vitiligo patients, with weaker suppressive effect of Tregs on autologous CD8+T cells4 and decreased expression level of Foxp3 and cytotoxic T lymphocyte antigen‐4 (CTLA‐4) that induces the anergy of effector T cells.6 Therefore, amending the impaired function of Tregs is another way to reconstruct the autoimmune tolerance and may be applied to the treatment for vitiligo. This evidence concerns the gene CTLA4 and vitiligo.