CNTNAP2 and autism spectrum disorder: More recently, the putative role of OT in modulation of complex neuropsychiatric disorders including autism spectrum disorders (ASD) and schizophrenia where it has undergone investigation as a therapeutic, has been the subject of considerable controversy.2–4 In one study, mice with a mutation in Cntnap2, which in humans leads to autistic spectrum disorders, experienced social deficits and lower levels of brain OT.