As many genes are associated with epileptic encephalopathy and hypotonia besides PIGA and related GPI biosynthesis gene, and there have been a wide range of medicine in clinical use with many of which being directed to a particular genotype (e.g., quinidine is a specific medicine for KCNT1 epileptic encephalopathy genotype) (Fukuoka et al., 2017), a solid genotype determination is needed to guide the treatment. The gene discussed is PIGA; the disease is Epileptic encephalopathy.