Somatic mutations in PIGA affecting splicing have been described in several PNH cases, in which the mutations reside mostly in the splice donor or receptor sites, and may severely affect or completely abolish native splicing, leading to exon skipping or evocation of cryptic splice sites (Maugard et al.,1997; Takeda et al., 1993). Here, PIGA is linked to paroxysmal nocturnal hemoglobinuria.