This composite may drive pluripotency via SOX2‐OCT4 and switch on lineage‐related genes through Oct4's recruitment of Tcf/Lef factors.23 As a high level of OCT4 expression was detected in the Eca109 cell line,28 we inhibited the expression of OCT4 via the lentiviral infection system with plasmid vectors encoding OCT4‐shRNA. This evidence concerns the gene HNF4A and infection.