The circulating kisspeptin levels achieved by pharmacological administration of kisspeptin during this study are also observed in humans physiologically during pregnancy due to placental kisspeptin production (1‐10 nM).46 Therefore, the higher circulating kisspeptin levels during normal pregnancy may play a physiological role to enhance insulin secretion to protect the mother and foetus from increasing glucose levels and the development of gestational diabetes mellitus. Here, KISS1 is linked to gestational diabetes.