There are neuroanatomical and functional connections between kisspeptin and important hypothalamic appetite‐regulating neuropeptides.15, 16, 17 Intracerebroventricular administration of kisspeptin has been reported to alter food intake in mice18 and chicks,19 while other studies report no effect of kisspeptin administration on appetite in rats.20 In addition, impaired kisspeptin signalling disrupts metabolism and promotes glucose intolerance and obesity in mice.21 Here, KISS1 is linked to obesity due to melanocortin 4 receptor deficiency.