They either activate, as in the case of AG, or repress as in the case of PI, AP1, and AP3 CRC expression in the developing flower and restrict CRC expression to nectaries and carpels (Gomez-Mena et al., 2005; Lee et al., 2005; Ó’Maoiléidigh et al., 2013). The gene discussed is RENBP; the disease is colorectal carcinoma.