In contrast, an anti-tumorigenic role for Smad7 has been recently reported by Wang and colleagues, who showed that nuclear reporter subfamily 2, group F, and member 2 (NR2F2), a molecule involved in many cancers, induces a TGFβ1-dependent epithelial–mesenchymal transition by inhibiting Smad7, thus promoting CRC metastasizing process (99). This evidence concerns the gene TGFB1 and colorectal carcinoma.