TGFB1 and colitis: Mice with deletion of TGF-β signaling in DCs due to a selective lack of TβR2 develop systemic autoimmunity and colitis, the later being characterized by loss of goblet cells and marked mucosal lymphocytic infiltration with altered Tregs differentiation, T cells and B cells with an activated phenotype, and increased expression of pro-inflammatory cytokines (52, 53).