As ER stress has also been linked to the pathogenesis of Crohn’s disease (50), and as we demonstrated that ER stress regulates NKG2D-ligands on intestinal epithelial cells, we subsequently investigated the functional consequences of epithelial ER stress-induced NKG2D-ligand expression and its role in the development of spontaneous enteritis in a mouse model of this condition. This evidence concerns the gene KLRK1 and enteritis.