Yuan et al. (2003) reported annonacin (1), a mono-tetrahydrofuran acetogenin isolated from the seeds of A. reticulata, induced the cell cycle detention at the G1 phase in T24 bladder cancer cells by causing stimulation of p21, and also caused cytotoxicity in a Bax and caspase-3-related pathway. Here, CASP3 is linked to urinary bladder cancer.