However, in past few decades, multiple treatments, including Aβ immunization (Holmes et al., 2008; Doody et al., 2013) and administration of β-secretase inhibitors (Mikulca et al., 2014), γ-secretase inhibitors (Mikulca et al., 2014; Doody et al., 2016), and tau aggregation inhibitors (Gauthier et al., 2016), have proven to be insufficient to cure AD. Here, MAPT is linked to Alzheimer disease.