In peripheral tissues, inhibition of SOCS3 has been proven to activate insulin signaling (Torisu et al., 2007; Sachithanandan et al., 2010; Jorgensen et al., 2013), and expression of SOCS3 is increased in the brains of individuals with AD (Walker et al., 2015; Iwahara et al., 2017). Here, SOCS3 is linked to Alzheimer disease.