SOCS3 and Insulin resistance: Several studies have examined the genetic regulation of SOCS3 in different peripheral organs to determine its role in the generation of insulin resistance; these studies have shown that SOCS3 deletion results in the loss of insulin resistance and in enhanced effects of insulin signaling, as evidenced by increased tyrosine phosphorylation of IRS1 (Torisu et al., 2007; Sachithanandan et al., 2010; Jorgensen et al., 2013).