Under the CDRV infection, the greatest up-regulated proteins (over 5 folds) were serum amyloid protein (U3IC83) and alpha-1-acid glycoprotein (U3I466); and the greatest down-regulated proteins were malic enzyme (U3IL38), fatty acid synthase (R0KBE2), and acetoacetyl-CoA synthetase (U3IQX8) (Table S2). The gene discussed is ORM1; the disease is infection.