FGF21 and hydrops fetalis: These morphological changes in adipose tissue were also accompanied by significant increases in circulating leptin levels (Fig. 5B) as well as adipose fibroblast growth factor-21 (FGF21) levels (Fig. 5C) in mice fed the HF diet and the HF diet supplemented with isoquercetin or inulin when compared to the normal chow diet.