CDK4 and gastric cancer: After overexpression of miR-99b-5p/203a-3p in GC cells, the results of western blot analysis demonstrated that miR-99b-5p/203a-3p expression reduced the expression of cyclin D1, CDK4/6 (Fig. 2D) and Bcl-2 (Fig. 2F), as well as upregulated Bax.