INS and Insulin resistance: Moreover, GWAS central datasets42, generated by performing a meta-analysis of up to 21 GWAS informative for fasting glucose, fasting insulin and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 non-diabetic participants, demonstrated that for +49 G/A and CT60, only a significant association of +49 G/A was observed with fasting plasma glucose level (P = 0.01711).