CTLA4 and autoimmune disease: Previous study reported that CT60 (rs3087243) in the 3′-UTR of CTLA-4 gene was identified as the principal marker for genetic risk14, and CTLA-4 +49 G/A (rs231775), another most studied tagSNP in Asians with moderate LD (r2 = 0.55) to CT60, causes an amino acid exchange (threonine to alanine) and has been shown to be associated with several autoimmune diseases, including type 1 diabetes12,16.