We found that 55 DEGs were up-regulated (including appetite regulation and nutrient response-related genes, IL1B, DUSP1 and RXRA), while 36 DEGs (including CCND1) were down-regulated in PBMCs samples both from PPD patients and IS mice (Fig. 3). The gene discussed is CCND1; the disease is progressive pseudorheumatoid arthropathy of childhood.